NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory nerve fibers in this abnormal cell fate decision is investigated using a severe extremity injury model in mice. So...

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Detalles Bibliográficos
Autores principales: Lee, Seungyong, Hwang, Charles, Marini, Simone, Tower, Robert J., Qin, Qizhi, Negri, Stefano, Pagani, Chase A., Sun, Yuxiao, Stepien, David M., Sorkin, Michael, Kubiak, Carrie A., Visser, Noelle D., Meyers, Carolyn A., Wang, Yiyun, Rasheed, Husain A., Xu, Jiajia, Miller, Sarah, Huber, Amanda K., Minichiello, Liliana, Cederna, Paul S., Kemp, Stephen W. P., Clemens, Thomas L., James, Aaron W., Levi, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368242/
https://www.ncbi.nlm.nih.gov/pubmed/34400627
http://dx.doi.org/10.1038/s41467-021-25143-z

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