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BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells

BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of naïve CD4+ T cells and the IFN-γ production of CD4+ T cells without increasing regulatory T c...

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Autores principales: Huang, Feng, Hu, Lei, Zhang, Yuanmin, Qu, Xingmin, Xu, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368433/
https://www.ncbi.nlm.nih.gov/pubmed/34413854
http://dx.doi.org/10.3389/fimmu.2021.702211
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author Huang, Feng
Hu, Lei
Zhang, Yuanmin
Qu, Xingmin
Xu, Junji
author_facet Huang, Feng
Hu, Lei
Zhang, Yuanmin
Qu, Xingmin
Xu, Junji
author_sort Huang, Feng
collection PubMed
description BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of naïve CD4+ T cells and the IFN-γ production of CD4+ T cells without increasing regulatory T cells. BMP4 could also moderate glycolysis of T cells and regulate Hif1α expression. Furthermore, BMP4 showed a suppressive function on the IFN-γ production of CD4+ T cells in vivo. These findings indicating a mechanism by which BMP-4 may regulate activation and IFN-γ production in CD4+ T cells via metabolism moderation and suggests that BMP4 may be a potential therapeutic supplement in autoinflammatory diseases.
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spelling pubmed-83684332021-08-18 BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells Huang, Feng Hu, Lei Zhang, Yuanmin Qu, Xingmin Xu, Junji Front Immunol Immunology BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of naïve CD4+ T cells and the IFN-γ production of CD4+ T cells without increasing regulatory T cells. BMP4 could also moderate glycolysis of T cells and regulate Hif1α expression. Furthermore, BMP4 showed a suppressive function on the IFN-γ production of CD4+ T cells in vivo. These findings indicating a mechanism by which BMP-4 may regulate activation and IFN-γ production in CD4+ T cells via metabolism moderation and suggests that BMP4 may be a potential therapeutic supplement in autoinflammatory diseases. Frontiers Media S.A. 2021-08-03 /pmc/articles/PMC8368433/ /pubmed/34413854 http://dx.doi.org/10.3389/fimmu.2021.702211 Text en Copyright © 2021 Huang, Hu, Zhang, Qu and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Feng
Hu, Lei
Zhang, Yuanmin
Qu, Xingmin
Xu, Junji
BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title_full BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title_fullStr BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title_full_unstemmed BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title_short BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
title_sort bmp4 moderates glycolysis and regulates activation and interferon-gamma production in cd4+ t cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368433/
https://www.ncbi.nlm.nih.gov/pubmed/34413854
http://dx.doi.org/10.3389/fimmu.2021.702211
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