Cargando…
Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population
INTRODUCTION: Donor liver graft quality plays an especially important role that contributes to the success of organ transplantation. Almost all local and international authors are interested in the techniques and results of transplantation, however, in Vietnam, there have not been any studies that r...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369000/ https://www.ncbi.nlm.nih.gov/pubmed/34429944 http://dx.doi.org/10.1016/j.amsu.2021.102654 |
_version_ | 1783739198248845312 |
---|---|
author | Nguyen, Thanh Khiem Trinh, Hong Son Luong, Tuan Hiep Ninh, Viet Khai Pham, Gia Anh Nguyen, Ham Hoi Bui, Trung Nghia Dang, Kim Khue Hoang, Tuan Nguyen, Quang Nghia |
author_facet | Nguyen, Thanh Khiem Trinh, Hong Son Luong, Tuan Hiep Ninh, Viet Khai Pham, Gia Anh Nguyen, Ham Hoi Bui, Trung Nghia Dang, Kim Khue Hoang, Tuan Nguyen, Quang Nghia |
author_sort | Nguyen, Thanh Khiem |
collection | PubMed |
description | INTRODUCTION: Donor liver graft quality plays an especially important role that contributes to the success of organ transplantation. Almost all local and international authors are interested in the techniques and results of transplantation, however, in Vietnam, there have not been any studies that report the results of liver procurement from brain-dead donors from a technical perspective as well as the morphology and function of the transplanted organ. MATERIALS AND METHOD: This study is descriptive cross-section study with analysis of retrospective occurrences of a series of cases of liver procurement from brain-dead donors from March 2010 to March 2020. All cases were proceeded the multiple organ procurement with warm liver dissection and in vivo cannulation and perfusion. RESULTS: The average age of brain-dead donors was 29.7 ± 10.7 (18–69), 92.16% of the harvested organs were of good quality macroscopically; and the rate of anatomical modification was 33.3% that occurred mostly in the left hepatic artery (LHA). Technically, warm dissection was proceeded in majority of cases (98,0%), the graft implantation was performed by this technique with mean cold ischemia time (CIT) of 190,0 ± 100,5 min and WIT of 74,0 ± 39,2 s. There were no complications relating to graft injuries occurring during procurement and no primary liver failure, good results accounted for 94.1% of the total number of transplants postoperatively. CONCLUSION: Multiple organ procurement with warm liver dissection and in vivo cannulation and perfusion was a safe technique and may be effective by avoiding any donor's damages in cold-phase dissection. |
format | Online Article Text |
id | pubmed-8369000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83690002021-08-23 Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population Nguyen, Thanh Khiem Trinh, Hong Son Luong, Tuan Hiep Ninh, Viet Khai Pham, Gia Anh Nguyen, Ham Hoi Bui, Trung Nghia Dang, Kim Khue Hoang, Tuan Nguyen, Quang Nghia Ann Med Surg (Lond) Case Series INTRODUCTION: Donor liver graft quality plays an especially important role that contributes to the success of organ transplantation. Almost all local and international authors are interested in the techniques and results of transplantation, however, in Vietnam, there have not been any studies that report the results of liver procurement from brain-dead donors from a technical perspective as well as the morphology and function of the transplanted organ. MATERIALS AND METHOD: This study is descriptive cross-section study with analysis of retrospective occurrences of a series of cases of liver procurement from brain-dead donors from March 2010 to March 2020. All cases were proceeded the multiple organ procurement with warm liver dissection and in vivo cannulation and perfusion. RESULTS: The average age of brain-dead donors was 29.7 ± 10.7 (18–69), 92.16% of the harvested organs were of good quality macroscopically; and the rate of anatomical modification was 33.3% that occurred mostly in the left hepatic artery (LHA). Technically, warm dissection was proceeded in majority of cases (98,0%), the graft implantation was performed by this technique with mean cold ischemia time (CIT) of 190,0 ± 100,5 min and WIT of 74,0 ± 39,2 s. There were no complications relating to graft injuries occurring during procurement and no primary liver failure, good results accounted for 94.1% of the total number of transplants postoperatively. CONCLUSION: Multiple organ procurement with warm liver dissection and in vivo cannulation and perfusion was a safe technique and may be effective by avoiding any donor's damages in cold-phase dissection. Elsevier 2021-07-31 /pmc/articles/PMC8369000/ /pubmed/34429944 http://dx.doi.org/10.1016/j.amsu.2021.102654 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Series Nguyen, Thanh Khiem Trinh, Hong Son Luong, Tuan Hiep Ninh, Viet Khai Pham, Gia Anh Nguyen, Ham Hoi Bui, Trung Nghia Dang, Kim Khue Hoang, Tuan Nguyen, Quang Nghia Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title | Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title_full | Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title_fullStr | Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title_full_unstemmed | Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title_short | Technical characteristics and quality of grafts in liver procurement from brain-dead donors: A single-center study in Vietnamese population |
title_sort | technical characteristics and quality of grafts in liver procurement from brain-dead donors: a single-center study in vietnamese population |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369000/ https://www.ncbi.nlm.nih.gov/pubmed/34429944 http://dx.doi.org/10.1016/j.amsu.2021.102654 |
work_keys_str_mv | AT nguyenthanhkhiem technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT trinhhongson technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT luongtuanhiep technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT ninhvietkhai technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT phamgiaanh technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT nguyenhamhoi technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT buitrungnghia technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT dangkimkhue technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT hoangtuan technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation AT nguyenquangnghia technicalcharacteristicsandqualityofgraftsinliverprocurementfrombraindeaddonorsasinglecenterstudyinvietnamesepopulation |