Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

Mutual Exclusivity analysis of genomic aberrations contributes to the exploration of potential synthetic lethal (SL) relationships thus guiding the nomination of specific cancer cells vulnerabilities. When multiple classes of genomic aberrations and large cohorts of patients are interrogated, exhaus...

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Detalles Bibliográficos
Autores principales: Fedrizzi, Tarcisio, Ciani, Yari, Lorenzin, Francesca, Cantore, Thomas, Gasperini, Paola, Demichelis, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369001/
https://www.ncbi.nlm.nih.gov/pubmed/34429855
http://dx.doi.org/10.1016/j.csbj.2021.08.001

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