Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity

The interaction of the Fc region of therapeutic antibodies and antibody-drug conjugates with Fcγ receptors (FcγRs) can lead to unpredictable and severe side effects. Over the last decades several strategies have been developed to overcome this drawback, including extensive Fc- and glycoengineering a...

Descripción completa

Detalles Bibliográficos
Autores principales: Elter, Adrian, Yanakieva, Desislava, Fiebig, David, Hallstein, Kerstin, Becker, Stefan, Betz, Ulrich, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369199/
https://www.ncbi.nlm.nih.gov/pubmed/34413859
http://dx.doi.org/10.3389/fimmu.2021.715719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369199/
https://www.ncbi.nlm.nih.gov/pubmed/34413859
http://dx.doi.org/10.3389/fimmu.2021.715719

Ejemplares similares