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Ergotamine Induced Retroperitoneal Fibrosis

Retroperitoneal fibrosis (RPF) is an uncommon disease characterised by the presence of fibroinflammatory reaction which starts around the infrarenal portion of the abdominal aorta in the retroperitoneum and frequently entrap the ureter causing obstructive uropathy. Approximately, two thirds of the c...

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Autores principales: Patra, Susama, Padhi, Somanath, Padhan, Prasanta, Kar, Madhabananda, Nayak, Prasant, Samal, Subash Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Mediterranean Journal of Rheumatology (MJR) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369278/
https://www.ncbi.nlm.nih.gov/pubmed/34447915
http://dx.doi.org/10.31138/mjr.32.2.168
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author Patra, Susama
Padhi, Somanath
Padhan, Prasanta
Kar, Madhabananda
Nayak, Prasant
Samal, Subash Chandra
author_facet Patra, Susama
Padhi, Somanath
Padhan, Prasanta
Kar, Madhabananda
Nayak, Prasant
Samal, Subash Chandra
author_sort Patra, Susama
collection PubMed
description Retroperitoneal fibrosis (RPF) is an uncommon disease characterised by the presence of fibroinflammatory reaction which starts around the infrarenal portion of the abdominal aorta in the retroperitoneum and frequently entrap the ureter causing obstructive uropathy. Approximately, two thirds of the cases are idiopathic, where aetiopathogenesis is not known. Ergotamine-induced RPF, although rare, is considered under secondary group. The fibrogenic process here is thought to be due to serotonergic activity. We report a case of RPF in a young female with obstructive uropathy who had history of long-term ergotamine intake for migraine. Histopathological evaluation revealed different evolving stages of necrotising vasculitis. In addition, the patient has responded to withdrawal of offending drug along with immunosuppressive therapy. We believe, apart from serotonergic activity, ergotamine can lead to RPF through a vasculitic process which has not been reported earlier.
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spelling pubmed-83692782021-08-25 Ergotamine Induced Retroperitoneal Fibrosis Patra, Susama Padhi, Somanath Padhan, Prasanta Kar, Madhabananda Nayak, Prasant Samal, Subash Chandra Mediterr J Rheumatol Case Report Retroperitoneal fibrosis (RPF) is an uncommon disease characterised by the presence of fibroinflammatory reaction which starts around the infrarenal portion of the abdominal aorta in the retroperitoneum and frequently entrap the ureter causing obstructive uropathy. Approximately, two thirds of the cases are idiopathic, where aetiopathogenesis is not known. Ergotamine-induced RPF, although rare, is considered under secondary group. The fibrogenic process here is thought to be due to serotonergic activity. We report a case of RPF in a young female with obstructive uropathy who had history of long-term ergotamine intake for migraine. Histopathological evaluation revealed different evolving stages of necrotising vasculitis. In addition, the patient has responded to withdrawal of offending drug along with immunosuppressive therapy. We believe, apart from serotonergic activity, ergotamine can lead to RPF through a vasculitic process which has not been reported earlier. The Mediterranean Journal of Rheumatology (MJR) 2021-06-30 /pmc/articles/PMC8369278/ /pubmed/34447915 http://dx.doi.org/10.31138/mjr.32.2.168 Text en © 2021 The Mediterranean Journal of Rheumatology (MJR) https://creativecommons.org/licenses/by/4.0/This work is licensed under and Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Case Report
Patra, Susama
Padhi, Somanath
Padhan, Prasanta
Kar, Madhabananda
Nayak, Prasant
Samal, Subash Chandra
Ergotamine Induced Retroperitoneal Fibrosis
title Ergotamine Induced Retroperitoneal Fibrosis
title_full Ergotamine Induced Retroperitoneal Fibrosis
title_fullStr Ergotamine Induced Retroperitoneal Fibrosis
title_full_unstemmed Ergotamine Induced Retroperitoneal Fibrosis
title_short Ergotamine Induced Retroperitoneal Fibrosis
title_sort ergotamine induced retroperitoneal fibrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369278/
https://www.ncbi.nlm.nih.gov/pubmed/34447915
http://dx.doi.org/10.31138/mjr.32.2.168
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