Cargando…

Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage

In patients with atrial fibrillation, left atrial appendage (LAA) occlusion devices represent an alternative to anticoagulation but are associated with residual peridevice leaks (PDLs) and device-related thrombi (DRT). Similarly, cerebrovascular aneurysms can be treated with coil embolization, but p...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishnan, Subramaniam C., Natale, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369292/
https://www.ncbi.nlm.nih.gov/pubmed/34430948
http://dx.doi.org/10.1016/j.hroo.2021.06.004
_version_ 1783739262420647936
author Krishnan, Subramaniam C.
Natale, Andrea
author_facet Krishnan, Subramaniam C.
Natale, Andrea
author_sort Krishnan, Subramaniam C.
collection PubMed
description In patients with atrial fibrillation, left atrial appendage (LAA) occlusion devices represent an alternative to anticoagulation but are associated with residual peridevice leaks (PDLs) and device-related thrombi (DRT). Similarly, cerebrovascular aneurysms can be treated with coil embolization, but pericoil leaks represent a significant limitation. In experimental models of cerebrovascular aneurysms, endothelial denudation achieved independently with (1) embolization with radioactive coils, (2) mechanical removal of the endothelium, or (3) radiofrequency ablation was dramatically effective in preventing or eliminating pericoil leaks. Anatomical, physiological, and blood flow similarities exist between the LAA and saccular aneurysms. Concepts developed in treating aneurysm leaks can be used to treat similar problems in the LAA. Learning from aneurysms, we conceived of a novel technique to denude local endothelium and thus eliminate residual leaks around LAA-occlusion devices. We recently successfully tested this hypothesis in patients with a PDL in a prospective manner in a multicenter study. In this article, we expand on the rationale of the technique developed to close PDLs and potentially also prevent DRTs.
format Online
Article
Text
id pubmed-8369292
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83692922021-08-23 Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage Krishnan, Subramaniam C. Natale, Andrea Heart Rhythm O2 Topics in Review In patients with atrial fibrillation, left atrial appendage (LAA) occlusion devices represent an alternative to anticoagulation but are associated with residual peridevice leaks (PDLs) and device-related thrombi (DRT). Similarly, cerebrovascular aneurysms can be treated with coil embolization, but pericoil leaks represent a significant limitation. In experimental models of cerebrovascular aneurysms, endothelial denudation achieved independently with (1) embolization with radioactive coils, (2) mechanical removal of the endothelium, or (3) radiofrequency ablation was dramatically effective in preventing or eliminating pericoil leaks. Anatomical, physiological, and blood flow similarities exist between the LAA and saccular aneurysms. Concepts developed in treating aneurysm leaks can be used to treat similar problems in the LAA. Learning from aneurysms, we conceived of a novel technique to denude local endothelium and thus eliminate residual leaks around LAA-occlusion devices. We recently successfully tested this hypothesis in patients with a PDL in a prospective manner in a multicenter study. In this article, we expand on the rationale of the technique developed to close PDLs and potentially also prevent DRTs. Elsevier 2021-06-23 /pmc/articles/PMC8369292/ /pubmed/34430948 http://dx.doi.org/10.1016/j.hroo.2021.06.004 Text en © 2021 Heart Rhythm Society. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Topics in Review
Krishnan, Subramaniam C.
Natale, Andrea
Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title_full Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title_fullStr Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title_full_unstemmed Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title_short Lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
title_sort lessons learned from experimental models of cerebrovascular aneurysms to improve endocardial device occlusion of the left atrial appendage
topic Topics in Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369292/
https://www.ncbi.nlm.nih.gov/pubmed/34430948
http://dx.doi.org/10.1016/j.hroo.2021.06.004
work_keys_str_mv AT krishnansubramaniamc lessonslearnedfromexperimentalmodelsofcerebrovascularaneurysmstoimproveendocardialdeviceocclusionoftheleftatrialappendage
AT nataleandrea lessonslearnedfromexperimentalmodelsofcerebrovascularaneurysmstoimproveendocardialdeviceocclusionoftheleftatrialappendage