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The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch
The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. C. elegans expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369342/ https://www.ncbi.nlm.nih.gov/pubmed/34414364 http://dx.doi.org/10.17912/micropub.biology.000439 |
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author | Kaulich, Eva Walker, Denise S Tang, Yi-Quan Schafer, William Ronald |
author_facet | Kaulich, Eva Walker, Denise S Tang, Yi-Quan Schafer, William Ronald |
author_sort | Kaulich, Eva |
collection | PubMed |
description | The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. C. elegans expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in both muscles and the nervous system. This wide expression pattern suggests that TMC-1 might serve different functions in the various neurons. TMC-1 has previously been shown to function in neurons, playing a role in chemosensation in the ASH neurons and mechanosensation in OLQ neurons, further supporting this hypothesis. tmc-1 is expressed in the high-threshold mechanosensory neuron, ALA. We show that tmc-1 mutants show defects in the ALA-dependent inhibition of egg-laying in response to a harsh mechanical stimulus. |
format | Online Article Text |
id | pubmed-8369342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-83693422021-08-18 The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch Kaulich, Eva Walker, Denise S Tang, Yi-Quan Schafer, William Ronald MicroPubl Biol New Finding The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. C. elegans expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in both muscles and the nervous system. This wide expression pattern suggests that TMC-1 might serve different functions in the various neurons. TMC-1 has previously been shown to function in neurons, playing a role in chemosensation in the ASH neurons and mechanosensation in OLQ neurons, further supporting this hypothesis. tmc-1 is expressed in the high-threshold mechanosensory neuron, ALA. We show that tmc-1 mutants show defects in the ALA-dependent inhibition of egg-laying in response to a harsh mechanical stimulus. Caltech Library 2021-08-16 /pmc/articles/PMC8369342/ /pubmed/34414364 http://dx.doi.org/10.17912/micropub.biology.000439 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Kaulich, Eva Walker, Denise S Tang, Yi-Quan Schafer, William Ronald The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title | The Caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title_full | The Caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title_fullStr | The Caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title_full_unstemmed | The Caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title_short | The Caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
title_sort | caenorhabditis elegans
tmc-1 is involved in egg-laying inhibition in response to harsh touch |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369342/ https://www.ncbi.nlm.nih.gov/pubmed/34414364 http://dx.doi.org/10.17912/micropub.biology.000439 |
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