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Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses
Bioreactance is the continuous analysis of transthoracic voltage variation in response to an applied high frequency transthoracic current and was recently introduced for non-invasive cardiac output measurement (NICOM). We evaluated NICOM compared to thermodilution (TD) in adult horses. Six healthy h...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369349/ https://www.ncbi.nlm.nih.gov/pubmed/34414227 http://dx.doi.org/10.3389/fvets.2021.701339 |
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author | Hopster, Klaus Hurcombe, Samuel D. A. |
author_facet | Hopster, Klaus Hurcombe, Samuel D. A. |
author_sort | Hopster, Klaus |
collection | PubMed |
description | Bioreactance is the continuous analysis of transthoracic voltage variation in response to an applied high frequency transthoracic current and was recently introduced for non-invasive cardiac output measurement (NICOM). We evaluated NICOM compared to thermodilution (TD) in adult horses. Six healthy horses were used for this prospective, blinded, experimental study. Cardiac output (CO) measurements were performed simultaneously using TD and the bioreactance method. Different cardiac output scenarios were established using xylazine (0.5 mg/kg IV) and dobutamine (1.5–3 mcg/kg/min). Statistical analysis was performed by calculating the concordance rate, performing a regression analysis, Pearson correlation, and Bland Altman. The TD-based CO and NICOM values were highly correlated for low, normal and high CO values with an overall correlation coefficient. A 4-quadrant plot showed an 89% rate of concordance. The linear regression calculated a relationship between NICOM and TDCO of Y = 0.4874 · X + 0.5936. For the corrected Bland Altman agreement, the mean bias and lower/upper limits of agreement were −0.26 and −3.88 to 3.41 L/min, respectively. Compared to TD, bioreactance- based NICOM showed good accuracy at induced low, normal, and high CO states in normal horses. Future studies performed under more clinical conditions will show if this monitor can help to assess hemodynamic status and guide therapy in horses in ICU settings and under general anesthesia. |
format | Online Article Text |
id | pubmed-8369349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83693492021-08-18 Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses Hopster, Klaus Hurcombe, Samuel D. A. Front Vet Sci Veterinary Science Bioreactance is the continuous analysis of transthoracic voltage variation in response to an applied high frequency transthoracic current and was recently introduced for non-invasive cardiac output measurement (NICOM). We evaluated NICOM compared to thermodilution (TD) in adult horses. Six healthy horses were used for this prospective, blinded, experimental study. Cardiac output (CO) measurements were performed simultaneously using TD and the bioreactance method. Different cardiac output scenarios were established using xylazine (0.5 mg/kg IV) and dobutamine (1.5–3 mcg/kg/min). Statistical analysis was performed by calculating the concordance rate, performing a regression analysis, Pearson correlation, and Bland Altman. The TD-based CO and NICOM values were highly correlated for low, normal and high CO values with an overall correlation coefficient. A 4-quadrant plot showed an 89% rate of concordance. The linear regression calculated a relationship between NICOM and TDCO of Y = 0.4874 · X + 0.5936. For the corrected Bland Altman agreement, the mean bias and lower/upper limits of agreement were −0.26 and −3.88 to 3.41 L/min, respectively. Compared to TD, bioreactance- based NICOM showed good accuracy at induced low, normal, and high CO states in normal horses. Future studies performed under more clinical conditions will show if this monitor can help to assess hemodynamic status and guide therapy in horses in ICU settings and under general anesthesia. Frontiers Media S.A. 2021-08-03 /pmc/articles/PMC8369349/ /pubmed/34414227 http://dx.doi.org/10.3389/fvets.2021.701339 Text en Copyright © 2021 Hopster and Hurcombe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Hopster, Klaus Hurcombe, Samuel D. A. Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title | Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title_full | Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title_fullStr | Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title_full_unstemmed | Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title_short | Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses |
title_sort | agreement of bioreactance cardiac output monitoring with thermodilution in healthy standing horses |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369349/ https://www.ncbi.nlm.nih.gov/pubmed/34414227 http://dx.doi.org/10.3389/fvets.2021.701339 |
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