Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities are not completely understood. Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRAS mutants with biva...

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Detalles Bibliográficos
Autores principales: Terranova, Christopher J., Tang, Ming, Maitituoheti, Mayinuer, Raman, Ayush T., Ghosh, Archit K., Schulz, Jonathan, Amin, Samir B., Orouji, Elias, Tomczak, Katarzyna, Sarkar, Sharmistha, Oba, Junna, Creasy, Caitlin, Wu, Chang-Jiun, Khan, Samia, Lazcano, Rossana, Wani, Khalida, Singh, Anand, Barrodia, Praveen, Zhao, Dongyu, Chen, Kaifu, Haydu, Lauren E., Wang, Wei-Lien, Lazar, Alexander J., Woodman, Scott E., Bernatchez, Chantale, Rai, Kunal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369408/
https://www.ncbi.nlm.nih.gov/pubmed/34289358
http://dx.doi.org/10.1016/j.celrep.2021.109410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369408/
https://www.ncbi.nlm.nih.gov/pubmed/34289358
http://dx.doi.org/10.1016/j.celrep.2021.109410

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