Cargando…

The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases

Inflammatory diseases have a negative impact on bone homeostasis via exacerbated local and systemic inflammation. Bone resorbing osteoclasts are mainly derived from hematopoietic precursors and bone marrow monocytes. Induced osteoclastogenesis during inflammation, autoimmunity, metabolic diseases, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Zhou, Pathak, Janak L., Ge, Linhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369417/
https://www.ncbi.nlm.nih.gov/pubmed/34414191
http://dx.doi.org/10.3389/fcell.2021.713254
_version_ 1783739288656019456
author Fan, Zhou
Pathak, Janak L.
Ge, Linhu
author_facet Fan, Zhou
Pathak, Janak L.
Ge, Linhu
author_sort Fan, Zhou
collection PubMed
description Inflammatory diseases have a negative impact on bone homeostasis via exacerbated local and systemic inflammation. Bone resorbing osteoclasts are mainly derived from hematopoietic precursors and bone marrow monocytes. Induced osteoclastogenesis during inflammation, autoimmunity, metabolic diseases, and cancers is associated with bone loss and osteoporosis. Proinflammatory cytokines, pathogen-associated molecular patterns, or endogenous pathogenic factors induce osteoclastogenic differentiation by binding to the Toll-like receptor (TLR) family expressed on surface of osteoclast precursors. As a non-canonical member of the TLRs, radioprotective 105 kDa (RP105 or CD180) and its ligand, myeloid differentiation protein 1 (MD1), are involved in several bone metabolic disorders. Reports from literature had demonstrated RP105 as an important activator of B cells, bone marrow monocytes, and macrophages, which regulates inflammatory cytokines release from immune cells. Reports from literature had shown the association between RP105 and other TLRs, and the downstream signaling mechanisms of RP105 with different “signaling-competent” partners in immune cells during different disease conditions. This review is focused to summarize: (1) the role of RP105 on immune cells’ function and inflammation regulation (2) the potential regulatory roles of RP105 in different disease-mediated osteoclast activation and the underlying mechanisms, and (3) the different “signaling-competent” partners of RP105 that regulates osteoclastogenesis.
format Online
Article
Text
id pubmed-8369417
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83694172021-08-18 The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases Fan, Zhou Pathak, Janak L. Ge, Linhu Front Cell Dev Biol Cell and Developmental Biology Inflammatory diseases have a negative impact on bone homeostasis via exacerbated local and systemic inflammation. Bone resorbing osteoclasts are mainly derived from hematopoietic precursors and bone marrow monocytes. Induced osteoclastogenesis during inflammation, autoimmunity, metabolic diseases, and cancers is associated with bone loss and osteoporosis. Proinflammatory cytokines, pathogen-associated molecular patterns, or endogenous pathogenic factors induce osteoclastogenic differentiation by binding to the Toll-like receptor (TLR) family expressed on surface of osteoclast precursors. As a non-canonical member of the TLRs, radioprotective 105 kDa (RP105 or CD180) and its ligand, myeloid differentiation protein 1 (MD1), are involved in several bone metabolic disorders. Reports from literature had demonstrated RP105 as an important activator of B cells, bone marrow monocytes, and macrophages, which regulates inflammatory cytokines release from immune cells. Reports from literature had shown the association between RP105 and other TLRs, and the downstream signaling mechanisms of RP105 with different “signaling-competent” partners in immune cells during different disease conditions. This review is focused to summarize: (1) the role of RP105 on immune cells’ function and inflammation regulation (2) the potential regulatory roles of RP105 in different disease-mediated osteoclast activation and the underlying mechanisms, and (3) the different “signaling-competent” partners of RP105 that regulates osteoclastogenesis. Frontiers Media S.A. 2021-08-03 /pmc/articles/PMC8369417/ /pubmed/34414191 http://dx.doi.org/10.3389/fcell.2021.713254 Text en Copyright © 2021 Fan, Pathak and Ge. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Fan, Zhou
Pathak, Janak L.
Ge, Linhu
The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title_full The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title_fullStr The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title_full_unstemmed The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title_short The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases
title_sort potential role of rp105 in regulation of inflammation and osteoclastogenesis during inflammatory diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369417/
https://www.ncbi.nlm.nih.gov/pubmed/34414191
http://dx.doi.org/10.3389/fcell.2021.713254
work_keys_str_mv AT fanzhou thepotentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases
AT pathakjanakl thepotentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases
AT gelinhu thepotentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases
AT fanzhou potentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases
AT pathakjanakl potentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases
AT gelinhu potentialroleofrp105inregulationofinflammationandosteoclastogenesisduringinflammatorydiseases