In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax

[Image: see text] Anthrax is caused by Bacillus anthracis and can result in nearly 100% mortality due in part to anthrax toxin. Antimalarial amodiaquine (AQ) acts as a host-oriented inhibitor of anthrax toxin endocytosis. Here, we determined the pharmacokinetics and safety of AQ in mice, rabbits, an...

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Autores principales: Martchenko Shilman, Mikhail, Bartolo, Gloria, Alameh, Saleem, Peterson, Johnny W., Lawrence, William S., Peel, Jennifer E., Sivasubramani, Satheesh K., Beasley, David W. C., Cote, Christopher K., Demons, Samandra T., Halasahoris, Stephanie A., Miller, Lynda L., Klimko, Christopher P., Shoe, Jennifer L., Fetterer, David P., McComb, Ryan, Ho, Chi-Lee C., Bradley, Kenneth A., Hartmann, Stella, Cheng, Luisa W., Chugunova, Marina, Kao, Chiu-Yen, Tran, Jennifer K., Derbedrossian, Aram, Zilbermintz, Leeor, Amali-Adekwu, Emiene, Levitin, Anastasia, West, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369491/
https://www.ncbi.nlm.nih.gov/pubmed/34218660
http://dx.doi.org/10.1021/acsinfecdis.1c00190

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