Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors

[Image: see text] Commercial carbapenem antibiotics are being used to treat multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis. Like other β-lactams, carbapenems are irreversible inhibitors of serine d,d-transpeptidases involved in peptidoglycan biosynthesis. In addition to...

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Detalles Bibliográficos
Autores principales: Gupta, Rashmi, Al-Kharji, Noora M. S. A., Alqurafi, Maha A., Nguyen, Thu Q., Chai, Weirui, Quan, Pojun, Malhotra, Riya, Simcox, Breven S., Mortimer, Phil, Brammer Basta, Leighanne A., Rohde, Kyle H., Buynak, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369493/
https://www.ncbi.nlm.nih.gov/pubmed/34191496
http://dx.doi.org/10.1021/acsinfecdis.1c00185

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