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CoCoA-diff: counterfactual inference for single-cell gene expression analysis
Finding a causal gene is a fundamental problem in genomic medicine. We present a causal inference framework, CoCoA-diff, that prioritizes disease genes by adjusting confounders without prior knowledge of control variables in single-cell RNA-seq data. We demonstrate that our method substantially impr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369635/ https://www.ncbi.nlm.nih.gov/pubmed/34404460 http://dx.doi.org/10.1186/s13059-021-02438-4 |