Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B

[Image: see text] Activation-induced cytidine deaminase (AID) initiates antibody diversification by mutating immunoglobulin loci in B lymphocytes. AID and related APOBEC3 (A3) enzymes also induce genome-wide mutations and lesions implicated in tumorigenesis and tumor progression. The most prevalent...

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Autores principales: King, Justin J., Borzooee, Faezeh, Im, Junbum, Asgharpour, Mahdi, Ghorbani, Atefeh, Diamond, Cody P., Fifield, Heather, Berghuis, Lesley, Larijani, Mani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369683/
https://www.ncbi.nlm.nih.gov/pubmed/34423273
http://dx.doi.org/10.1021/acsptsci.1c00091

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