Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although...

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Autores principales: Liu, Yingyue, Zhou, Xiangxiang, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369706/
https://www.ncbi.nlm.nih.gov/pubmed/34404434
http://dx.doi.org/10.1186/s13045-021-01134-x
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author Liu, Yingyue
Zhou, Xiangxiang
Wang, Xin
author_facet Liu, Yingyue
Zhou, Xiangxiang
Wang, Xin
author_sort Liu, Yingyue
collection PubMed
description B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies.
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spelling pubmed-83697062021-08-18 Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities Liu, Yingyue Zhou, Xiangxiang Wang, Xin J Hematol Oncol Review B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies. BioMed Central 2021-08-17 /pmc/articles/PMC8369706/ /pubmed/34404434 http://dx.doi.org/10.1186/s13045-021-01134-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Yingyue
Zhou, Xiangxiang
Wang, Xin
Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title_full Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title_fullStr Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title_full_unstemmed Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title_short Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
title_sort targeting the tumor microenvironment in b-cell lymphoma: challenges and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369706/
https://www.ncbi.nlm.nih.gov/pubmed/34404434
http://dx.doi.org/10.1186/s13045-021-01134-x
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