Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity

BACKGROUND: Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has physiological functions in the central nervous system, but also is involved in m...

Descripción completa

Detalles Bibliográficos
Autores principales: Gregersen, Emil, Betzer, Cristine, Kim, Woojin S., Kovacs, Gergo, Reimer, Lasse, Halliday, Glenda M., Thiel, Steffen, Jensen, Poul Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369722/
https://www.ncbi.nlm.nih.gov/pubmed/34399786
http://dx.doi.org/10.1186/s12974-021-02225-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369722/
https://www.ncbi.nlm.nih.gov/pubmed/34399786
http://dx.doi.org/10.1186/s12974-021-02225-9

Ejemplares similares