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Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity

BACKGROUND: Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has physiological functions in the central nervous system, but also is involved in m...

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Detalles Bibliográficos
Autores principales:	Gregersen, Emil, Betzer, Cristine, Kim, Woojin S., Kovacs, Gergo, Reimer, Lasse, Halliday, Glenda M., Thiel, Steffen, Jensen, Poul Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369722/ https://www.ncbi.nlm.nih.gov/pubmed/34399786 http://dx.doi.org/10.1186/s12974-021-02225-9

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