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4-Methylumbelliferone suppresses catabolic activation in anterior cruciate ligament-derived cells via a mechanism independent of hyaluronan inhibition

BACKGROUND: The anterior cruciate ligament (ACL) has a key role as a dynamic stabilizer of the knee joints, and ACL dysfunction caused by traumatic or degenerative rupture accelerates osteoarthritis progression. Thus, it is important to prevent the degenerative rupture of the ACL. 4-Methylumbellifer...

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Detalles Bibliográficos
Autores principales:	Idota, Masaru, Ishizuka, Shinya, Hiraiwa, Hideki, Yamashita, Satoshi, Oba, Hiroki, Kawamura, Yusuke, Sakaguchi, Takefumi, Haga, Takahiro, Mizuno, Takafumi, Kawashima, Itaru, Kuriyama, Kanae, Imagama, Shiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369759/ https://www.ncbi.nlm.nih.gov/pubmed/34404442 http://dx.doi.org/10.1186/s13018-021-02637-6

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