CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a periodontitis model in SD rats

BACKGROUND: We previously demonstrated that nasal administration of periodontitis gene vaccine (pVAX1-HA2-fimA) or pVAX1-HA2-fimA plus IL-15 as adjuvant provoked protective immunity in the periodontal tissue of SD rats. This study evaluated the immune effect of pVAX1-HA2-fimA plus CpG-ODN 1826 as an...

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Detalles Bibliográficos
Autores principales: Bai, Guohui, Yu, Hang, Guan, Xiaoyan, Zeng, Fengjiao, Liu, Xia, Chen, Bin, Liu, Jianguo, Tian, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369760/
https://www.ncbi.nlm.nih.gov/pubmed/34399747
http://dx.doi.org/10.1186/s12903-021-01763-1

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