Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC‐1 tumor‐bearing mice with PD‐1 blockade by modulating macrophage heterogeneity and the activation of CD8(+) T cells in the tumor microenvironment

OBJECTIVES: Developing a vaccine formula that alters the tumor‐infiltrating lymphocytes to be more immune active against a tumor is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen‐specific immunotherapy, and IL‐10 and PD‐1 bloc...

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Detalles Bibliográficos
Autores principales: Ni, Guoying, Yang, Xiaodan, Li, Junjie, Wu, Xiaolian, Liu, Ying, Li, Hejie, Chen, Shu, Fogarty, Conor E, Frazer, Ian H, Chen, Guoqiang, Liu, Xiaosong, Wang, Tianfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369845/
https://www.ncbi.nlm.nih.gov/pubmed/34429969
http://dx.doi.org/10.1002/cti2.1335

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