In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology

In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and small intestine, and predicting CYP3A4‐mediated drug m...

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Detalles Bibliográficos
Autores principales: Deguchi, Sayaka, Shintani, Tomohiro, Harada, Kazuo, Okamoto, Toru, Takemura, Akinori, Hirata, Kazumasa, Ito, Kousei, Takayama, Kazuo, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369939/
https://www.ncbi.nlm.nih.gov/pubmed/34430783
http://dx.doi.org/10.1002/hep4.1729

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