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Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder
Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369985/ https://www.ncbi.nlm.nih.gov/pubmed/34422464 http://dx.doi.org/10.7759/cureus.16425 |
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author | Ding, Jack B Hu, Kevin |
author_facet | Ding, Jack B Hu, Kevin |
author_sort | Ding, Jack B |
collection | PubMed |
description | Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data. |
format | Online Article Text |
id | pubmed-8369985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-83699852021-08-20 Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder Ding, Jack B Hu, Kevin Cureus Neurology Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data. Cureus 2021-07-16 /pmc/articles/PMC8369985/ /pubmed/34422464 http://dx.doi.org/10.7759/cureus.16425 Text en Copyright © 2021, Ding et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurology Ding, Jack B Hu, Kevin Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title | Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title_full | Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title_fullStr | Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title_full_unstemmed | Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title_short | Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder |
title_sort | structural mri brain alterations in borderline personality disorder and bipolar disorder |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369985/ https://www.ncbi.nlm.nih.gov/pubmed/34422464 http://dx.doi.org/10.7759/cureus.16425 |
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