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Extensive thrombosis after COVID-19 vaccine: cause or coincidence?

A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries...

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Autores principales: Graça, Luís Lourenço, Amaral, Maria João, Serôdio, Marco, Costa, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370539/
https://www.ncbi.nlm.nih.gov/pubmed/34400433
http://dx.doi.org/10.1136/bcr-2021-244878
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author Graça, Luís Lourenço
Amaral, Maria João
Serôdio, Marco
Costa, Beatriz
author_facet Graça, Luís Lourenço
Amaral, Maria João
Serôdio, Marco
Costa, Beatriz
author_sort Graça, Luís Lourenço
collection PubMed
description A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, and extensive thrombosis of the superior and inferior mesenteric veins, splenic and portal veins, and the inferior vena cava, extending to the left common iliac vein. The spleen displayed extensive areas of infarction. Aetiological investigation included assessment of congenital coagulation disorders and acquired causes with no relevant findings. Administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal thrombosis. After reviewing relevant literature, it was considered that other causes of this event should be further investigated. Thrombosis associated with COVID-19 vaccine is rare and an aetiological relationship should only be considered in the appropriate context and after investigation of other, more frequent, causes.
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spelling pubmed-83705392021-08-31 Extensive thrombosis after COVID-19 vaccine: cause or coincidence? Graça, Luís Lourenço Amaral, Maria João Serôdio, Marco Costa, Beatriz BMJ Case Rep Case Report A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, and extensive thrombosis of the superior and inferior mesenteric veins, splenic and portal veins, and the inferior vena cava, extending to the left common iliac vein. The spleen displayed extensive areas of infarction. Aetiological investigation included assessment of congenital coagulation disorders and acquired causes with no relevant findings. Administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal thrombosis. After reviewing relevant literature, it was considered that other causes of this event should be further investigated. Thrombosis associated with COVID-19 vaccine is rare and an aetiological relationship should only be considered in the appropriate context and after investigation of other, more frequent, causes. BMJ Publishing Group 2021-08-16 /pmc/articles/PMC8370539/ /pubmed/34400433 http://dx.doi.org/10.1136/bcr-2021-244878 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Graça, Luís Lourenço
Amaral, Maria João
Serôdio, Marco
Costa, Beatriz
Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title_full Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title_fullStr Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title_full_unstemmed Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title_short Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
title_sort extensive thrombosis after covid-19 vaccine: cause or coincidence?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370539/
https://www.ncbi.nlm.nih.gov/pubmed/34400433
http://dx.doi.org/10.1136/bcr-2021-244878
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