The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation

The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity. We circumvented this issue with a well-tested strat...

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Detalles Bibliográficos
Autores principales: Levandowski, Cecilia B., Jones, Taylor, Gruca, Margaret, Ramamoorthy, Sivapriya, Dowell, Robin D., Taatjes, Dylan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370613/
https://www.ncbi.nlm.nih.gov/pubmed/34351910
http://dx.doi.org/10.1371/journal.pbio.3001364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370613/
https://www.ncbi.nlm.nih.gov/pubmed/34351910
http://dx.doi.org/10.1371/journal.pbio.3001364

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