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Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo

HSV glycoprotein K (gK) is an essential herpes protein that contributes to enhancement of eye disease. We previously reported that gK binds to signal peptide peptidase (SPP) and that depletion of SPP reduces HSV-1 infectivity in vivo. To determine the therapeutic potential of blocking gK binding to...

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Detalles Bibliográficos
Autores principales:	Wang, Shaohui, Jaggi, Ujjaldeep, Yu, Jack, Ghiasi, Homayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370620/ https://www.ncbi.nlm.nih.gov/pubmed/34352042 http://dx.doi.org/10.1371/journal.ppat.1009848

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