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EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

Viruses suppress immune recognition through diverse mechanisms. Epstein-Barr Virus (EBV) establishes latent infection in memory B-lymphocytes and B-cell malignancies where it impacts B-cell immune function. We show here that EBV primary infection of naïve B-cells results in a robust down-regulation...

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Detalles Bibliográficos
Autores principales:	Su, Chenhe, Lu, Fang, Soldan, Samantha S., Lamontagne, R. Jason, Tang, Hsin-Yao, Napoletani, Giorgia, Farrell, Paul J., Tempera, Italo, Kossenkov, Andrew V., Lieberman, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370649/ https://www.ncbi.nlm.nih.gov/pubmed/34352044 http://dx.doi.org/10.1371/journal.ppat.1009834

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