An information-theory analysis of DNA methylation identifies converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia

In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA-methylation analyses must capture epigenetic variability, which is central to tumour heterogeneity and tumour plasticity. Here, by conducting a comprehensive analysis, based on information...

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Detalles Bibliográficos
Autores principales: Koldobskiy, Michael A., Jenkinson, Garrett, Abante, Jordi, DiBlasi, Varenka A. Rodriguez, Zhou, Weiqiang, Pujadas, Elisabet, Idrizi, Adrian, Tryggvadottir, Rakel, Callahan, Colin, Bonifant, Challice L., Rabin, Karen R., Brown, Patrick A., Ji, Hongkai, Goutsias, John, Feinberg, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370714/
https://www.ncbi.nlm.nih.gov/pubmed/33859388
http://dx.doi.org/10.1038/s41551-021-00703-2

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