Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compound C/Dorsomorphin. Here, we studied the effe...

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Detalles Bibliográficos
Autores principales: Ahwazi, Danial, Neopane, Katyayanee, Markby, Greg R., Kopietz, Franziska, Ovens, Ashley J., Dall, Morten, Hassing, Anna S., Gräsle, Pamina, Alshuweishi, Yazeed, Treebak, Jonas T., Salt, Ian P., Göransson, Olga, Zeqiraj, Elton, Scott, John W., Sakamoto, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370752/
https://www.ncbi.nlm.nih.gov/pubmed/34259310
http://dx.doi.org/10.1042/BCJ20210284

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