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Angiomatoid Fibrous Histiocytoma: A Series of Three Cases

Angiomatoid fibrous histiocytoma (AFH) is a rare, slow-growing soft tissue tumor with an intermediate biologic potential and uncertain line of differentiation, and minimal metastatic potential. AFH may mimic both the clinical, histological, and radiological findings of several tumors; therefore, it...

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Autores principales: Alzahim, Mohammed A, Abed, Abdulaziz H, Mashrah, Hosam T, Almahdaly, Akeel M, Shaheen, Mahmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370762/
https://www.ncbi.nlm.nih.gov/pubmed/34422494
http://dx.doi.org/10.7759/cureus.16465
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author Alzahim, Mohammed A
Abed, Abdulaziz H
Mashrah, Hosam T
Almahdaly, Akeel M
Shaheen, Mahmood
author_facet Alzahim, Mohammed A
Abed, Abdulaziz H
Mashrah, Hosam T
Almahdaly, Akeel M
Shaheen, Mahmood
author_sort Alzahim, Mohammed A
collection PubMed
description Angiomatoid fibrous histiocytoma (AFH) is a rare, slow-growing soft tissue tumor with an intermediate biologic potential and uncertain line of differentiation, and minimal metastatic potential. AFH may mimic both the clinical, histological, and radiological findings of several tumors; therefore, it is frequently misdiagnosed.  Three cases of AFH were included in this study. A six-year-old male and two females with an age of 12 and 17 years are presented. The primary locations were in the right shoulder (case 1), left medial proximal thigh (case 2), and left lateral knee (case 3). Two cases (cases 2&3) were presented with a painful mass. In the three patients, the masses were firm, mobile, and not attached to the skin.  Magnetic resonance imaging (MRI) was done, illustrating unspecific findings to reach a diagnosis. Needle biopsies were performed in all patient, and the diagnosis of AFH was reached. All three patients underwent wide surgical excision of the tumor. Patients were followed up routinely every three to four months with imaging studies to rule out recurrence and metastasis, for a period of 15 months (case 1), 26 months (case 2), and 19 months (case 3), which all resulted negatively. 
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spelling pubmed-83707622021-08-20 Angiomatoid Fibrous Histiocytoma: A Series of Three Cases Alzahim, Mohammed A Abed, Abdulaziz H Mashrah, Hosam T Almahdaly, Akeel M Shaheen, Mahmood Cureus Physical Medicine & Rehabilitation Angiomatoid fibrous histiocytoma (AFH) is a rare, slow-growing soft tissue tumor with an intermediate biologic potential and uncertain line of differentiation, and minimal metastatic potential. AFH may mimic both the clinical, histological, and radiological findings of several tumors; therefore, it is frequently misdiagnosed.  Three cases of AFH were included in this study. A six-year-old male and two females with an age of 12 and 17 years are presented. The primary locations were in the right shoulder (case 1), left medial proximal thigh (case 2), and left lateral knee (case 3). Two cases (cases 2&3) were presented with a painful mass. In the three patients, the masses were firm, mobile, and not attached to the skin.  Magnetic resonance imaging (MRI) was done, illustrating unspecific findings to reach a diagnosis. Needle biopsies were performed in all patient, and the diagnosis of AFH was reached. All three patients underwent wide surgical excision of the tumor. Patients were followed up routinely every three to four months with imaging studies to rule out recurrence and metastasis, for a period of 15 months (case 1), 26 months (case 2), and 19 months (case 3), which all resulted negatively.  Cureus 2021-07-18 /pmc/articles/PMC8370762/ /pubmed/34422494 http://dx.doi.org/10.7759/cureus.16465 Text en Copyright © 2021, Alzahim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Physical Medicine & Rehabilitation
Alzahim, Mohammed A
Abed, Abdulaziz H
Mashrah, Hosam T
Almahdaly, Akeel M
Shaheen, Mahmood
Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title_full Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title_fullStr Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title_full_unstemmed Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title_short Angiomatoid Fibrous Histiocytoma: A Series of Three Cases
title_sort angiomatoid fibrous histiocytoma: a series of three cases
topic Physical Medicine & Rehabilitation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370762/
https://www.ncbi.nlm.nih.gov/pubmed/34422494
http://dx.doi.org/10.7759/cureus.16465
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