Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies there is no therapeutic regimen for this deltaretrovirus. Here, we screened a library of integrase strand transfer inhibitor (INSTI) candidat...

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Detalles Bibliográficos
Autores principales: Barski, Michal S., Vanzo, Teresa, Zhao, Xue Zhi, Smith, Steven J., Ballandras-Colas, Allison, Cronin, Nora B., Pye, Valerie E., Hughes, Stephen H., Burke, Terrence R., Cherepanov, Peter, Maertens, Goedele N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370991/
https://www.ncbi.nlm.nih.gov/pubmed/34404793
http://dx.doi.org/10.1038/s41467-021-25284-1

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