Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses

Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of how RB-loss changes human cells. Here we show that pRB-depletion results in cellular reprogramming, we quantitatively measured how RB-depletion altered the transcriptional, proteomic and metabolic outpu...

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Detalles Bibliográficos
Autores principales: Rajasekaran, Swetha, Siddiqui, Jalal, Rakijas, Jessica, Nicolay, Brandon, Lin, Chenyu, Khan, Eshan, Patel, Rahi, Morris, Robert, Wyler, Emanuel, Boukhali, Myriam, Balasubramanyam, Jayashree, Ranjith Kumar, R., Van Rechem, Capucine, Vogel, Christine, Elchuri, Sailaja V., Landthaler, Markus, Obermayer, Benedikt, Haas, Wilhelm, Dyson, Nicholas, Miles, Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371045/
https://www.ncbi.nlm.nih.gov/pubmed/34404904
http://dx.doi.org/10.1038/s42003-021-02495-2

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