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Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping

Studies have shown the spatial specificity of cranial iron deposition in different regions in Parkinson's disease (PD). However, the time-specific patterns of iron deposition are not yet clear. The purpose of this study was to investigate the time pattern of iron variations and its clinical rel...

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Autores principales: Fu, Xiaodi, Deng, Wenbin, Cui, Xiangqin, Zhou, Xiao, Song, Weizheng, Pan, Mengqiu, Chi, Xiao, Xu, Jinghui, Jiang, Ying, Wang, Qun, Xu, Yunqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371047/
https://www.ncbi.nlm.nih.gov/pubmed/34421781
http://dx.doi.org/10.3389/fneur.2021.631210
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author Fu, Xiaodi
Deng, Wenbin
Cui, Xiangqin
Zhou, Xiao
Song, Weizheng
Pan, Mengqiu
Chi, Xiao
Xu, Jinghui
Jiang, Ying
Wang, Qun
Xu, Yunqi
author_facet Fu, Xiaodi
Deng, Wenbin
Cui, Xiangqin
Zhou, Xiao
Song, Weizheng
Pan, Mengqiu
Chi, Xiao
Xu, Jinghui
Jiang, Ying
Wang, Qun
Xu, Yunqi
author_sort Fu, Xiaodi
collection PubMed
description Studies have shown the spatial specificity of cranial iron deposition in different regions in Parkinson's disease (PD). However, the time-specific patterns of iron deposition are not yet clear. The purpose of this study was to investigate the time pattern of iron variations and its clinical relevance in multiple gray matter nuclei in PD using quantitative susceptibility mapping (QSM). Thirty controls and 33 PD patients were enrolled, namely, 11 cases of early stage of PD (ESP) and 22 cases of advanced stage of PD (ASP) according to the Hoehn-Yahr stages. The iron content in the subcortical nuclei covering substantia nigra (SN), red nucleus (RN), head of the caudate nucleus (CN), globus pallidus (GP), and putamen (PT) was measured using QSM, and the clinical symptoms of PD were evaluated by various rating scales. The QSM values in SN, RN, GP, and PT significantly increased in PD patients compared with the controls. Further subgroup comparison with the controls indicated that the iron content in SN and GP (paleostriatum) gradually elevated in the whole disease duration and was related to clinical features. While the iron content in RN and PT (neostriatum) only elevated significantly in ESP patients, further iron deposition was not obvious in ASP patients. Our study confirmed that QSM could be used as a disease biomarker and could be suitable for longitudinal monitoring. However, considering the temporal characteristics of iron deposition in neostriatum, iron deposition in the neostriatum should be paid more attention in the early stage of the disease, even in the preclinical stage, in future research.
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spelling pubmed-83710472021-08-19 Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping Fu, Xiaodi Deng, Wenbin Cui, Xiangqin Zhou, Xiao Song, Weizheng Pan, Mengqiu Chi, Xiao Xu, Jinghui Jiang, Ying Wang, Qun Xu, Yunqi Front Neurol Neurology Studies have shown the spatial specificity of cranial iron deposition in different regions in Parkinson's disease (PD). However, the time-specific patterns of iron deposition are not yet clear. The purpose of this study was to investigate the time pattern of iron variations and its clinical relevance in multiple gray matter nuclei in PD using quantitative susceptibility mapping (QSM). Thirty controls and 33 PD patients were enrolled, namely, 11 cases of early stage of PD (ESP) and 22 cases of advanced stage of PD (ASP) according to the Hoehn-Yahr stages. The iron content in the subcortical nuclei covering substantia nigra (SN), red nucleus (RN), head of the caudate nucleus (CN), globus pallidus (GP), and putamen (PT) was measured using QSM, and the clinical symptoms of PD were evaluated by various rating scales. The QSM values in SN, RN, GP, and PT significantly increased in PD patients compared with the controls. Further subgroup comparison with the controls indicated that the iron content in SN and GP (paleostriatum) gradually elevated in the whole disease duration and was related to clinical features. While the iron content in RN and PT (neostriatum) only elevated significantly in ESP patients, further iron deposition was not obvious in ASP patients. Our study confirmed that QSM could be used as a disease biomarker and could be suitable for longitudinal monitoring. However, considering the temporal characteristics of iron deposition in neostriatum, iron deposition in the neostriatum should be paid more attention in the early stage of the disease, even in the preclinical stage, in future research. Frontiers Media S.A. 2021-08-04 /pmc/articles/PMC8371047/ /pubmed/34421781 http://dx.doi.org/10.3389/fneur.2021.631210 Text en Copyright © 2021 Fu, Deng, Cui, Zhou, Song, Pan, Chi, Xu, Jiang, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fu, Xiaodi
Deng, Wenbin
Cui, Xiangqin
Zhou, Xiao
Song, Weizheng
Pan, Mengqiu
Chi, Xiao
Xu, Jinghui
Jiang, Ying
Wang, Qun
Xu, Yunqi
Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title_full Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title_fullStr Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title_full_unstemmed Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title_short Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
title_sort time-specific pattern of iron deposition in different regions in parkinson's disease measured by quantitative susceptibility mapping
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371047/
https://www.ncbi.nlm.nih.gov/pubmed/34421781
http://dx.doi.org/10.3389/fneur.2021.631210
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