Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing antibody (NAb) responses in rabbits. The trimers...

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Detalles Bibliográficos
Autores principales: Sliepen, Kwinten, Schermer, Edith, Bontjer, Ilja, Burger, Judith A., Lévai, Réka Felfödiné, Mundsperger, Philipp, Brouwer, Philip J. M., Tolazzi, Monica, Farsang, Attila, Katinger, Dietmar, Moore, John P., Scarlatti, Gabriella, Shattock, Robin J., Sattentau, Quentin J., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371121/
https://www.ncbi.nlm.nih.gov/pubmed/34404812
http://dx.doi.org/10.1038/s41541-021-00364-x

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