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Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory

Prior behavioral and neuroimaging evidence supports a separation between working memory capacities in the phonological and orthographic domains. Although these data indicate distinct buffers for orthographic and phonological information, prior neural evidence does indicate that nearby left inferior...

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Autores principales: Purcell, Jeremy, Rapp, Brenda, Martin, Randi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371181/
https://www.ncbi.nlm.nih.gov/pubmed/34421789
http://dx.doi.org/10.3389/fneur.2021.681141
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author Purcell, Jeremy
Rapp, Brenda
Martin, Randi C.
author_facet Purcell, Jeremy
Rapp, Brenda
Martin, Randi C.
author_sort Purcell, Jeremy
collection PubMed
description Prior behavioral and neuroimaging evidence supports a separation between working memory capacities in the phonological and orthographic domains. Although these data indicate distinct buffers for orthographic and phonological information, prior neural evidence does indicate that nearby left inferior parietal regions support both of these working memory capacities. Given that no study has directly compared their neural substrates based on data from the same individuals, it is possible that there is a common left inferior parietal region shared by both working memory capacities. In fact, those endorsing an embedded processes account of working memory might suggest that parietal involvement reflects a domain-general attentional system that directs attention to long-term memory representations in the two domains, implying that the same neural region supports the two capacities. Thus, in this work, a multivariate lesion-symptom mapping approach was used to assess the neural basis of phonological and orthographic working memory using behavioral and lesion data from the same set of 37 individuals. The results showed a separation of the neural substrates, with regions in the angular gyrus supporting orthographic working memory and with regions primarily in the supramarginal gyrus supporting phonological working memory. The results thus argue against the parietal involvement as supporting a domain-general attentional mechanism and support a domain-specific buffer account of working memory.
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spelling pubmed-83711812021-08-19 Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory Purcell, Jeremy Rapp, Brenda Martin, Randi C. Front Neurol Neurology Prior behavioral and neuroimaging evidence supports a separation between working memory capacities in the phonological and orthographic domains. Although these data indicate distinct buffers for orthographic and phonological information, prior neural evidence does indicate that nearby left inferior parietal regions support both of these working memory capacities. Given that no study has directly compared their neural substrates based on data from the same individuals, it is possible that there is a common left inferior parietal region shared by both working memory capacities. In fact, those endorsing an embedded processes account of working memory might suggest that parietal involvement reflects a domain-general attentional system that directs attention to long-term memory representations in the two domains, implying that the same neural region supports the two capacities. Thus, in this work, a multivariate lesion-symptom mapping approach was used to assess the neural basis of phonological and orthographic working memory using behavioral and lesion data from the same set of 37 individuals. The results showed a separation of the neural substrates, with regions in the angular gyrus supporting orthographic working memory and with regions primarily in the supramarginal gyrus supporting phonological working memory. The results thus argue against the parietal involvement as supporting a domain-general attentional mechanism and support a domain-specific buffer account of working memory. Frontiers Media S.A. 2021-08-04 /pmc/articles/PMC8371181/ /pubmed/34421789 http://dx.doi.org/10.3389/fneur.2021.681141 Text en Copyright © 2021 Purcell, Rapp and Martin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Purcell, Jeremy
Rapp, Brenda
Martin, Randi C.
Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title_full Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title_fullStr Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title_full_unstemmed Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title_short Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory
title_sort distinct neural substrates support phonological and orthographic working memory: implications for theories of working memory
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371181/
https://www.ncbi.nlm.nih.gov/pubmed/34421789
http://dx.doi.org/10.3389/fneur.2021.681141
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