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Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses

Human immunoglobulin G subclass 3 (IgG3) possesses a uniquely long hinge region that separates its Fab antigen-binding and Fc receptor-binding regions. Owing to this hinge length, the molecular structure of full-length IgG3 remains elusive, and the role of the two conserved Fc glycosylation sites ar...

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Detalles Bibliográficos
Autores principales:	Spiteri, Valentina A., Goodall, Margaret, Doutch, James, Rambo, Robert P., Gor, Jayesh, Perkins, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371214/ https://www.ncbi.nlm.nih.gov/pubmed/34302810 http://dx.doi.org/10.1016/j.jbc.2021.100995

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