Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inflammation involving type I interferon (IFN) and st...

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Detalles Bibliográficos
Autores principales: Bruand, Marine, Barras, David, Mina, Marco, Ghisoni, Eleonora, Morotti, Matteo, Lanitis, Evripidis, Fahr, Noémie, Desbuisson, Mathieu, Grimm, Alizée, Zhang, Hualing, Chong, Chloe, Dagher, Julien, Chee, Sora, Tsianou, Theodora, Dorier, Julien, Stevenson, Brian J., Iseli, Christian, Ronet, Catherine, Bobisse, Sara, Genolet, Raphael, Walton, Josephine, Bassani-Sternberg, Michal, Kandalaft, Lana E., Ren, Bing, McNeish, Iain, Swisher, Elizabeth, Harari, Alexandre, Delorenzi, Mauro, Ciriello, Giovanni, Irving, Melita, Rusakiewicz, Sylvie, Foukas, Periklis G., Martinon, Fabio, Dangaj Laniti, Denarda, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371260/
https://www.ncbi.nlm.nih.gov/pubmed/34289354
http://dx.doi.org/10.1016/j.celrep.2021.109412

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