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Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease

Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemak...

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Autores principales: Gao, Rui, Ren, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371477/
https://www.ncbi.nlm.nih.gov/pubmed/34422842
http://dx.doi.org/10.3389/fcell.2021.731402
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author Gao, Rui
Ren, Jie
author_facet Gao, Rui
Ren, Jie
author_sort Gao, Rui
collection PubMed
description Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemaker cardiomyocytes (CMs), atrioventricular node (AVN) and the ventricular conduction system (VCS), can shed light on the pathological and molecular mechanisms underlying CCD, provide approaches for generating human pluripotent stem cell (hPSC)-derived CCS cells, and thus improve therapeutic treatment for such a potentially life-threatening disorder of the heart. However, the cellular and molecular mechanisms controlling CCS development remain elusive. The zebrafish has become a valuable vertebrate model to investigate early development of CCS components because of its unique features such as external fertilization, embryonic optical transparency and the ability to survive even with severe cardiovascular defects during development. In this review, we highlight how the zebrafish has been utilized to dissect the cellular and molecular mechanisms of CCS development, and how the evolutionarily conserved developmental mechanisms discovered in zebrafish could be applied to directing the creation of hPSC-derived CCS cells, therefore providing potential therapeutic strategies that may contribute to better treatment for CCD patients.
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spelling pubmed-83714772021-08-19 Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease Gao, Rui Ren, Jie Front Cell Dev Biol Cell and Developmental Biology Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemaker cardiomyocytes (CMs), atrioventricular node (AVN) and the ventricular conduction system (VCS), can shed light on the pathological and molecular mechanisms underlying CCD, provide approaches for generating human pluripotent stem cell (hPSC)-derived CCS cells, and thus improve therapeutic treatment for such a potentially life-threatening disorder of the heart. However, the cellular and molecular mechanisms controlling CCS development remain elusive. The zebrafish has become a valuable vertebrate model to investigate early development of CCS components because of its unique features such as external fertilization, embryonic optical transparency and the ability to survive even with severe cardiovascular defects during development. In this review, we highlight how the zebrafish has been utilized to dissect the cellular and molecular mechanisms of CCS development, and how the evolutionarily conserved developmental mechanisms discovered in zebrafish could be applied to directing the creation of hPSC-derived CCS cells, therefore providing potential therapeutic strategies that may contribute to better treatment for CCD patients. Frontiers Media S.A. 2021-08-04 /pmc/articles/PMC8371477/ /pubmed/34422842 http://dx.doi.org/10.3389/fcell.2021.731402 Text en Copyright © 2021 Gao and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gao, Rui
Ren, Jie
Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title_full Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title_fullStr Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title_full_unstemmed Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title_short Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
title_sort zebrafish models in therapeutic research of cardiac conduction disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371477/
https://www.ncbi.nlm.nih.gov/pubmed/34422842
http://dx.doi.org/10.3389/fcell.2021.731402
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