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Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemak...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371477/ https://www.ncbi.nlm.nih.gov/pubmed/34422842 http://dx.doi.org/10.3389/fcell.2021.731402 |
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author | Gao, Rui Ren, Jie |
author_facet | Gao, Rui Ren, Jie |
author_sort | Gao, Rui |
collection | PubMed |
description | Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemaker cardiomyocytes (CMs), atrioventricular node (AVN) and the ventricular conduction system (VCS), can shed light on the pathological and molecular mechanisms underlying CCD, provide approaches for generating human pluripotent stem cell (hPSC)-derived CCS cells, and thus improve therapeutic treatment for such a potentially life-threatening disorder of the heart. However, the cellular and molecular mechanisms controlling CCS development remain elusive. The zebrafish has become a valuable vertebrate model to investigate early development of CCS components because of its unique features such as external fertilization, embryonic optical transparency and the ability to survive even with severe cardiovascular defects during development. In this review, we highlight how the zebrafish has been utilized to dissect the cellular and molecular mechanisms of CCS development, and how the evolutionarily conserved developmental mechanisms discovered in zebrafish could be applied to directing the creation of hPSC-derived CCS cells, therefore providing potential therapeutic strategies that may contribute to better treatment for CCD patients. |
format | Online Article Text |
id | pubmed-8371477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83714772021-08-19 Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease Gao, Rui Ren, Jie Front Cell Dev Biol Cell and Developmental Biology Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemaker cardiomyocytes (CMs), atrioventricular node (AVN) and the ventricular conduction system (VCS), can shed light on the pathological and molecular mechanisms underlying CCD, provide approaches for generating human pluripotent stem cell (hPSC)-derived CCS cells, and thus improve therapeutic treatment for such a potentially life-threatening disorder of the heart. However, the cellular and molecular mechanisms controlling CCS development remain elusive. The zebrafish has become a valuable vertebrate model to investigate early development of CCS components because of its unique features such as external fertilization, embryonic optical transparency and the ability to survive even with severe cardiovascular defects during development. In this review, we highlight how the zebrafish has been utilized to dissect the cellular and molecular mechanisms of CCS development, and how the evolutionarily conserved developmental mechanisms discovered in zebrafish could be applied to directing the creation of hPSC-derived CCS cells, therefore providing potential therapeutic strategies that may contribute to better treatment for CCD patients. Frontiers Media S.A. 2021-08-04 /pmc/articles/PMC8371477/ /pubmed/34422842 http://dx.doi.org/10.3389/fcell.2021.731402 Text en Copyright © 2021 Gao and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Gao, Rui Ren, Jie Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title | Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title_full | Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title_fullStr | Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title_full_unstemmed | Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title_short | Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease |
title_sort | zebrafish models in therapeutic research of cardiac conduction disease |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371477/ https://www.ncbi.nlm.nih.gov/pubmed/34422842 http://dx.doi.org/10.3389/fcell.2021.731402 |
work_keys_str_mv | AT gaorui zebrafishmodelsintherapeuticresearchofcardiacconductiondisease AT renjie zebrafishmodelsintherapeuticresearchofcardiacconductiondisease |