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The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19

BACKGROUND: COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study...

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Autores principales: Dincer Yazan, Ceyda, Ilgin, Can, Elbasan, Onur, Apaydin, Tugce, Dashdamirova, Saida, Yigit, Tayfun, Sili, Uluhan, Karahasan Yagci, Aysegul, Sirikci, Onder, Haklar, Goncagul, Gozu, Hulya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371668/
https://www.ncbi.nlm.nih.gov/pubmed/34422043
http://dx.doi.org/10.1155/2021/2395212
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author Dincer Yazan, Ceyda
Ilgin, Can
Elbasan, Onur
Apaydin, Tugce
Dashdamirova, Saida
Yigit, Tayfun
Sili, Uluhan
Karahasan Yagci, Aysegul
Sirikci, Onder
Haklar, Goncagul
Gozu, Hulya
author_facet Dincer Yazan, Ceyda
Ilgin, Can
Elbasan, Onur
Apaydin, Tugce
Dashdamirova, Saida
Yigit, Tayfun
Sili, Uluhan
Karahasan Yagci, Aysegul
Sirikci, Onder
Haklar, Goncagul
Gozu, Hulya
author_sort Dincer Yazan, Ceyda
collection PubMed
description BACKGROUND: COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. RESULTS: 34.1% of the patients were euthyroid. Length of hospitalization (p < 0.001), rate of oxygen demand (p < 0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.
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spelling pubmed-83716682021-08-19 The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 Dincer Yazan, Ceyda Ilgin, Can Elbasan, Onur Apaydin, Tugce Dashdamirova, Saida Yigit, Tayfun Sili, Uluhan Karahasan Yagci, Aysegul Sirikci, Onder Haklar, Goncagul Gozu, Hulya Int J Endocrinol Research Article BACKGROUND: COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. RESULTS: 34.1% of the patients were euthyroid. Length of hospitalization (p < 0.001), rate of oxygen demand (p < 0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease. Hindawi 2021-08-13 /pmc/articles/PMC8371668/ /pubmed/34422043 http://dx.doi.org/10.1155/2021/2395212 Text en Copyright © 2021 Ceyda Dincer Yazan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dincer Yazan, Ceyda
Ilgin, Can
Elbasan, Onur
Apaydin, Tugce
Dashdamirova, Saida
Yigit, Tayfun
Sili, Uluhan
Karahasan Yagci, Aysegul
Sirikci, Onder
Haklar, Goncagul
Gozu, Hulya
The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title_full The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title_fullStr The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title_full_unstemmed The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title_short The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
title_sort association of thyroid hormone changes with inflammatory status and prognosis in covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371668/
https://www.ncbi.nlm.nih.gov/pubmed/34422043
http://dx.doi.org/10.1155/2021/2395212
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