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The role of lymphatics in intestinal inflammation
The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesity, cardio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371859/ https://www.ncbi.nlm.nih.gov/pubmed/34404493 http://dx.doi.org/10.1186/s41232-021-00175-6 |
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author | Hokari, Ryota Tomioka, Akira |
author_facet | Hokari, Ryota Tomioka, Akira |
author_sort | Hokari, Ryota |
collection | PubMed |
description | The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesity, cardiovascular disease, hypertension, atherosclerosis, and Alzheimer’s disease. In this review, we discuss lymphatic structure and function within the gut, such as dietary lipid absorption, the transport of antigens and immune cells to lymph nodes, peripheral tolerance, and lymphocyte migration from secondary lymphoid tissues to the lymphatics and the immune systems. We also discuss the potential roles of these lymphatics on the pathophysiology of inflammatory bowel disease and as new targets for therapeutic management. |
format | Online Article Text |
id | pubmed-8371859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83718592021-08-18 The role of lymphatics in intestinal inflammation Hokari, Ryota Tomioka, Akira Inflamm Regen Review The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn’s disease, obesity, cardiovascular disease, hypertension, atherosclerosis, and Alzheimer’s disease. In this review, we discuss lymphatic structure and function within the gut, such as dietary lipid absorption, the transport of antigens and immune cells to lymph nodes, peripheral tolerance, and lymphocyte migration from secondary lymphoid tissues to the lymphatics and the immune systems. We also discuss the potential roles of these lymphatics on the pathophysiology of inflammatory bowel disease and as new targets for therapeutic management. BioMed Central 2021-08-17 /pmc/articles/PMC8371859/ /pubmed/34404493 http://dx.doi.org/10.1186/s41232-021-00175-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Hokari, Ryota Tomioka, Akira The role of lymphatics in intestinal inflammation |
title | The role of lymphatics in intestinal inflammation |
title_full | The role of lymphatics in intestinal inflammation |
title_fullStr | The role of lymphatics in intestinal inflammation |
title_full_unstemmed | The role of lymphatics in intestinal inflammation |
title_short | The role of lymphatics in intestinal inflammation |
title_sort | role of lymphatics in intestinal inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371859/ https://www.ncbi.nlm.nih.gov/pubmed/34404493 http://dx.doi.org/10.1186/s41232-021-00175-6 |
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