Ferroptosis, a New Insight Into Acute Lung Injury

Acute lung injury (ALI), a common and critical illness with high morbidity and mortality, is caused by multiple causes. It has been confirmed that oxidative stress plays an important role in the development of ALI. Ferroptosis, a newly discovered programmed cell death in 2012, is characterized by ir...

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Autores principales: Yin, Xiaofang, Zhu, Guisong, Wang, Qian, Fu, Yuan Dong, Wang, Juan, Xu, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371968/
https://www.ncbi.nlm.nih.gov/pubmed/34421604
http://dx.doi.org/10.3389/fphar.2021.709538
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author Yin, Xiaofang
Zhu, Guisong
Wang, Qian
Fu, Yuan Dong
Wang, Juan
Xu, Biao
author_facet Yin, Xiaofang
Zhu, Guisong
Wang, Qian
Fu, Yuan Dong
Wang, Juan
Xu, Biao
author_sort Yin, Xiaofang
collection PubMed
description Acute lung injury (ALI), a common and critical illness with high morbidity and mortality, is caused by multiple causes. It has been confirmed that oxidative stress plays an important role in the development of ALI. Ferroptosis, a newly discovered programmed cell death in 2012, is characterized by iron-dependent lipid peroxidation and involved in many diseases. To date, compelling evidence reveals the emerging role of ferroptosis in the pathophysiological process of ALI. Here, we review the role of ferroptosis in the pathogenesis of ALI and its therapeutic potential in ALI.
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spelling pubmed-83719682021-08-19 Ferroptosis, a New Insight Into Acute Lung Injury Yin, Xiaofang Zhu, Guisong Wang, Qian Fu, Yuan Dong Wang, Juan Xu, Biao Front Pharmacol Pharmacology Acute lung injury (ALI), a common and critical illness with high morbidity and mortality, is caused by multiple causes. It has been confirmed that oxidative stress plays an important role in the development of ALI. Ferroptosis, a newly discovered programmed cell death in 2012, is characterized by iron-dependent lipid peroxidation and involved in many diseases. To date, compelling evidence reveals the emerging role of ferroptosis in the pathophysiological process of ALI. Here, we review the role of ferroptosis in the pathogenesis of ALI and its therapeutic potential in ALI. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8371968/ /pubmed/34421604 http://dx.doi.org/10.3389/fphar.2021.709538 Text en Copyright © 2021 Yin, Zhu, Wang, Fu, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yin, Xiaofang
Zhu, Guisong
Wang, Qian
Fu, Yuan Dong
Wang, Juan
Xu, Biao
Ferroptosis, a New Insight Into Acute Lung Injury
title Ferroptosis, a New Insight Into Acute Lung Injury
title_full Ferroptosis, a New Insight Into Acute Lung Injury
title_fullStr Ferroptosis, a New Insight Into Acute Lung Injury
title_full_unstemmed Ferroptosis, a New Insight Into Acute Lung Injury
title_short Ferroptosis, a New Insight Into Acute Lung Injury
title_sort ferroptosis, a new insight into acute lung injury
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371968/
https://www.ncbi.nlm.nih.gov/pubmed/34421604
http://dx.doi.org/10.3389/fphar.2021.709538
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AT wangqian ferroptosisanewinsightintoacutelunginjury
AT fuyuandong ferroptosisanewinsightintoacutelunginjury
AT wangjuan ferroptosisanewinsightintoacutelunginjury
AT xubiao ferroptosisanewinsightintoacutelunginjury

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