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Metformin mitigates PLCε gene expression and modulates the Notch1/Hes and androgen receptor signaling pathways in castration-resistant prostate cancer xenograft models

The present study aimed to establish a mouse model of patient-derived castration-resistant prostate cancer (CRPC) xenograft tumors, and to evaluate the effects of various doses of metformin on phospholipase Cε (PLCε) expression and the neurogenic locus notch homolog protein 1 (Notch1)/hairy and enha...

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Detalles Bibliográficos
Autores principales:	Li, Qi, Xu, Ke, Tian, Jianguo, Lu, Zhicheng, Pu, Jianming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371978/ https://www.ncbi.nlm.nih.gov/pubmed/34429755 http://dx.doi.org/10.3892/ol.2021.12976

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