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Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or ext...

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Autores principales: Tehrani Fateh, Sepand, Moradi, Lida, Kohan, Elmira, Hamblin, Michael R, Shiralizadeh Dezfuli, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372309/
https://www.ncbi.nlm.nih.gov/pubmed/34476167
http://dx.doi.org/10.3762/bjnano.12.64
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author Tehrani Fateh, Sepand
Moradi, Lida
Kohan, Elmira
Hamblin, Michael R
Shiralizadeh Dezfuli, Amin
author_facet Tehrani Fateh, Sepand
Moradi, Lida
Kohan, Elmira
Hamblin, Michael R
Shiralizadeh Dezfuli, Amin
author_sort Tehrani Fateh, Sepand
collection PubMed
description The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.
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spelling pubmed-83723092021-09-01 Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications Tehrani Fateh, Sepand Moradi, Lida Kohan, Elmira Hamblin, Michael R Shiralizadeh Dezfuli, Amin Beilstein J Nanotechnol Review The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors. Beilstein-Institut 2021-08-11 /pmc/articles/PMC8372309/ /pubmed/34476167 http://dx.doi.org/10.3762/bjnano.12.64 Text en Copyright © 2021, Tehrani Fateh et al. https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjnano/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms/terms)
spellingShingle Review
Tehrani Fateh, Sepand
Moradi, Lida
Kohan, Elmira
Hamblin, Michael R
Shiralizadeh Dezfuli, Amin
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title_full Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title_fullStr Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title_full_unstemmed Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title_short Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
title_sort comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372309/
https://www.ncbi.nlm.nih.gov/pubmed/34476167
http://dx.doi.org/10.3762/bjnano.12.64
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