In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties

The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABA(A) receptors and the α2δ auxiliary subunit of V-gated Ca(2+) channels as putative targets because they are established as mediators of efficacious anxiolytics, antidepressants, and anticonvulsants. We furt...

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Detalles Bibliográficos
Autores principales: Malyshev, Anton V., Sukhanova, Iuliia A., Zlobin, Alexander S., Gedzun, Vasilina R., Pavshintsev, Vsevolod V., Vasileva, Ekaterina V., Zalevsky, Arthur O., Doronin, Igor I., Mitkin, Nikita A., Golovin, Andrey V., Lovat, Maxim L., Kovalev, Georgy I., Zolotarev, Yurii A., Kuchumov, Askar R., Babkin, Gennady A., Luscher, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372404/
https://www.ncbi.nlm.nih.gov/pubmed/34421525
http://dx.doi.org/10.3389/fnins.2021.705590

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