Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients

Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous r...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbate, Antonio, Gavin, Josh, Madanchi, Nima, Kim, Christin, Shah, Pranav R., Klein, Katherine, Boatman, Julie, Roberts, Charlotte, Patel, Seema, Danielides, Stamatina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372420/
https://www.ncbi.nlm.nih.gov/pubmed/34416319
http://dx.doi.org/10.1016/j.ijcard.2021.08.018
_version_ 1783739788913803264
author Abbate, Antonio
Gavin, Josh
Madanchi, Nima
Kim, Christin
Shah, Pranav R.
Klein, Katherine
Boatman, Julie
Roberts, Charlotte
Patel, Seema
Danielides, Stamatina
author_facet Abbate, Antonio
Gavin, Josh
Madanchi, Nima
Kim, Christin
Shah, Pranav R.
Klein, Katherine
Boatman, Julie
Roberts, Charlotte
Patel, Seema
Danielides, Stamatina
author_sort Abbate, Antonio
collection PubMed
description Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation.
format Online
Article
Text
id pubmed-8372420
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-83724202021-08-18 Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients Abbate, Antonio Gavin, Josh Madanchi, Nima Kim, Christin Shah, Pranav R. Klein, Katherine Boatman, Julie Roberts, Charlotte Patel, Seema Danielides, Stamatina Int J Cardiol Short Communication Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation. Elsevier B.V. 2021-10-01 2021-08-18 /pmc/articles/PMC8372420/ /pubmed/34416319 http://dx.doi.org/10.1016/j.ijcard.2021.08.018 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Abbate, Antonio
Gavin, Josh
Madanchi, Nima
Kim, Christin
Shah, Pranav R.
Klein, Katherine
Boatman, Julie
Roberts, Charlotte
Patel, Seema
Danielides, Stamatina
Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title_full Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title_fullStr Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title_full_unstemmed Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title_short Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients
title_sort fulminant myocarditis and systemic hyperinflammation temporally associated with bnt162b2 mrna covid-19 vaccination in two patients
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372420/
https://www.ncbi.nlm.nih.gov/pubmed/34416319
http://dx.doi.org/10.1016/j.ijcard.2021.08.018
work_keys_str_mv AT abbateantonio fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT gavinjosh fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT madanchinima fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT kimchristin fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT shahpranavr fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT kleinkatherine fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT boatmanjulie fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT robertscharlotte fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT patelseema fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients
AT danielidesstamatina fulminantmyocarditisandsystemichyperinflammationtemporallyassociatedwithbnt162b2mrnacovid19vaccinationintwopatients

Ejemplares similares