Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment during prophylaxis and therapy of K18-hACE2 mice intranasally infec...

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Autores principales: Ullah, Irfan, Prévost, Jérémie, Ladinsky, Mark S., Stone, Helen, Lu, Maolin, Anand, Sai Priya, Beaudoin-Bussières, Guillaume, Symmes, Kelly, Benlarbi, Mehdi, Ding, Shilei, Gasser, Romain, Fink, Corby, Chen, Yaozong, Tauzin, Alexandra, Goyette, Guillaume, Bourassa, Catherine, Medjahed, Halima, Mack, Matthias, Chung, Kunho, Wilen, Craig B., Dekaban, Gregory A., Dikeakos, Jimmy D., Bruce, Emily A., Kaufmann, Daniel E., Stamatatos, Leonidas, McGuire, Andrew T., Richard, Jonathan, Pazgier, Marzena, Bjorkman, Pamela J., Mothes, Walther, Finzi, Andrés, Kumar, Priti, Uchil, Pradeep D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372518/
https://www.ncbi.nlm.nih.gov/pubmed/34453881
http://dx.doi.org/10.1016/j.immuni.2021.08.015

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