A Concise Synthetic Strategy Towards the Novel Calcium-dependent Lipopeptide Antibiotic, Malacidin A and Analogues

Malacidin A is a novel calcium-dependent lipopeptide antibiotic with excellent activity against Gram-positive pathogens. Herein, a concise and robust synthetic route toward malacidin A is reported, employing 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis of a linear precursor, including la...

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Detalles Bibliográficos
Autores principales: Kovalenko, Nadiia, Howard, Georgina K., Swain, Jonathan A., Hermant, Yann, Cameron, Alan J., Cook, Gregory M., Ferguson, Scott A., Stubbing, Louise A., Harris, Paul W. R., Brimble, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372822/
https://www.ncbi.nlm.nih.gov/pubmed/34422759
http://dx.doi.org/10.3389/fchem.2021.687875

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