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Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas

This is the case of a 50-year-old male from the region of Urabá, Colombia, with a mixed infection by Rickettsia rickettsii and Leptospira interrogans serovar Copenhageni ST78 and negative test for malaria and dengue fever. The patient presented with febrile syndrome and was unresponsive to systemic...

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Autores principales: Ramírez-García, René, Quintero, Juan Carlos, Rosado, Aixa Paola, Arboleda, Margarita, González, Víctor Alejandro, Agudelo-Flórez, Piedad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Nacional de Salud 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372841/
https://www.ncbi.nlm.nih.gov/pubmed/34214261
http://dx.doi.org/10.7705/biomedica.5598
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author Ramírez-García, René
Quintero, Juan Carlos
Rosado, Aixa Paola
Arboleda, Margarita
González, Víctor Alejandro
Agudelo-Flórez, Piedad
author_facet Ramírez-García, René
Quintero, Juan Carlos
Rosado, Aixa Paola
Arboleda, Margarita
González, Víctor Alejandro
Agudelo-Flórez, Piedad
author_sort Ramírez-García, René
collection PubMed
description This is the case of a 50-year-old male from the region of Urabá, Colombia, with a mixed infection by Rickettsia rickettsii and Leptospira interrogans serovar Copenhageni ST78 and negative test for malaria and dengue fever. The patient presented with febrile syndrome and was unresponsive to systemic antibiotic treatment, who finally died in the intensive care unit. We established the postmortem diagnosis through molecular typification of the two etiological agents. In the inspection at the patient’s home, we found a Rattus rattus specimen infected with L. interrogans of the same serovar found in him. We found no ticks parasitizing the domestic animals cohabitating with the patient. This case of a mixed infection with progressive and fatal symptoms in a patient with occupational risk in a tropical disease endemic zone highlights the importance of considering the potential presentation of simultaneous etiologies in patients with multiple medical visits for unresolved febrile syndromes associated with risky exposure during agricultural activities.
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spelling pubmed-83728412021-08-19 Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas Ramírez-García, René Quintero, Juan Carlos Rosado, Aixa Paola Arboleda, Margarita González, Víctor Alejandro Agudelo-Flórez, Piedad Biomedica Reporte De Caso This is the case of a 50-year-old male from the region of Urabá, Colombia, with a mixed infection by Rickettsia rickettsii and Leptospira interrogans serovar Copenhageni ST78 and negative test for malaria and dengue fever. The patient presented with febrile syndrome and was unresponsive to systemic antibiotic treatment, who finally died in the intensive care unit. We established the postmortem diagnosis through molecular typification of the two etiological agents. In the inspection at the patient’s home, we found a Rattus rattus specimen infected with L. interrogans of the same serovar found in him. We found no ticks parasitizing the domestic animals cohabitating with the patient. This case of a mixed infection with progressive and fatal symptoms in a patient with occupational risk in a tropical disease endemic zone highlights the importance of considering the potential presentation of simultaneous etiologies in patients with multiple medical visits for unresolved febrile syndromes associated with risky exposure during agricultural activities. Instituto Nacional de Salud 2021-06-15 /pmc/articles/PMC8372841/ /pubmed/34214261 http://dx.doi.org/10.7705/biomedica.5598 Text en https://creativecommons.org/licenses/by/4.0/Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
spellingShingle Reporte De Caso
Ramírez-García, René
Quintero, Juan Carlos
Rosado, Aixa Paola
Arboleda, Margarita
González, Víctor Alejandro
Agudelo-Flórez, Piedad
Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title_full Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title_fullStr Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title_full_unstemmed Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title_short Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
title_sort leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas
topic Reporte De Caso
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372841/
https://www.ncbi.nlm.nih.gov/pubmed/34214261
http://dx.doi.org/10.7705/biomedica.5598
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