Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells

Adult T-cell leukemia/lymphoma (ATLL) originates from human T-cell leukemia virus type 1 (HTLV-1) infection due to the activation of the nuclear factor-κB (NF-κB) signaling pathway to maintain proliferation and survival. An important mechanism of the activated NF-κB signaling pathway in ATLL is the...

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Detalles Bibliográficos
Autores principales: Fauzi, Yanuar Rahmat, Nakahata, Shingo, Chilmi, Syahrul, Ichikawa, Tomonaga, Nueangphuet, Phawut, Yamaguchi, Ryoji, Nakamura, Tatsufumi, Shimoda, Kazuya, Morishita, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372904/
https://www.ncbi.nlm.nih.gov/pubmed/34407152
http://dx.doi.org/10.1371/journal.pone.0256320

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