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An Insight into Aging, Senescence, and Their Impacts on Wound Healing

Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent ce...

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Detalles Bibliográficos
Autores principales: Thanapaul, Rex Jeya Rajkumar Samdavid, Shvedova, Maria, Shin, Grace Haeun, Roh, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373038/
https://www.ncbi.nlm.nih.gov/pubmed/34414398
http://dx.doi.org/10.20900/agmr20210017
Descripción
Sumario:Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss of tissue homeostasis leading to dysregulation of normal and timely wound healing processes. The delays in wound healing of aging have widespread clinical and economic impacts, thus novel strategies to improve wound healing in aging are needed and targeting senescence may be a promising area.